Diuretics Interactions

Patients receiving diuretics should be observed carefully for development of cardiac arrhythmias.

Source: NLP:adrenalin (epinephrine)

Patients receiving epinephrine with diuretics should be observed carefully for development of cardiac arrhythmias.

Source: NLP:epinephrine, albuterol sulfate, nitroglycerin, diphenhydramine hydrochloride, aspirin

Increased risk of cardiac arrhythmias when used with epinephrine; careful observation required.

Source: NLP:auvi-q

Patients on diuretics may experience precipitous reduction of blood pressure within first hour after initial captopril dose, especially if recently started on diuretic therapy or on severe dietary salt restriction.

Source: NLP:captopril

Diuretics may induce hypokalemia or hypomagnesemia, which can precipitate QT prolongation with droperidol.

Source: NLP:droperidol

Diuretics augment antihypertensive effect and may cause excessive blood pressure reduction, especially if recently instituted. Close medical supervision required after initial dose.

Source: NLP:enalapril maleate

May cause excessive reduction of blood pressure after initiation of enalapril therapy, particularly if diuretic therapy was recently instituted.

Source: NLP:enalapril maleate and hydrochlorothiazide

Patients receiving epinephrine with diuretics should be observed carefully for development of cardiac arrhythmias.

Source: NLP:epinephrine

Patients receiving epinephrine with diuretics should be observed carefully for development of cardiac arrhythmias.

Source: NLP:epinephrine 0.15 pediatrics

May cause excessive reduction of blood pressure, especially in patients with intravascular volume depletion. Risk can be minimized by discontinuing diuretic, increasing salt intake, or reducing starting dose.

Source: NLP:fosinopril

Initiation of lisinopril in patients on diuretics may result in excessive reduction of blood pressure and hypotensive effects.

Source: NLP:lisinopril

Diuretics may cause excessive reduction of blood pressure after initiation of lisinopril therapy, especially if diuretic therapy was recently instituted. Close medical supervision is required.

Source: NLP:lisinopril and hydrochlorothiazide

Concomitant administration may potentiate the renal toxicity of mannitol; avoid use if possible.

Source: NLP:mannitol

Potassium-depleting agents administered with corticosteroids require close observation for development of hypokalemia.

Source: NLP:prednisone

Possibility of excessive hypotension, especially in patients with recently instituted diuretic therapy.

Source: NLP:ramipril

Avoid concomitant use due to increased risk of hyponatremia. If unavoidable, closely monitor serum sodium concentrations.

Source: NLP:dextrose monohydrate, sodium chloride, sodium lactate, potassium chloride, calcium chloride

Increased incidence of thrombocytopenia with purpura reported in elderly patients receiving certain diuretics, primarily thiazides.

Source: NLP:sulfamethoxazole and trimethoprim

Diuretics may produce hyperglycemia and lead to loss of blood glucose control. Patient should be closely observed for loss of blood glucose control.

Source: NLP:acarbose

Non-potassium-sparing diuretics may potentiate hypokalemia or ECG changes when combined with albuterol. Monitor potassium levels.

Source: NLP:albuterol sulfate and budesonide

May potentiate hypokalemia or ECG changes. Use with caution.

Source: NLP:arformoterol tartrate

Aspirin may diminish diuretic effectiveness in patients with renal or cardiovascular disease through inhibition of renal prostaglandins.

Source: NLP:aspirin and dipyridamole

Aspirin may diminish the effectiveness of diuretics in patients with renal or cardiovascular disease due to inhibition of renal prostaglandins.

Source: NLP:aspirin and extended-release dipyridamole

Excessive drop in blood pressure, especially with recent diuretic initiation. Potassium-sparing diuretics increase hyperkalemia risk.

Source: NLP:benazepril hydrochloride

Non-potassium-sparing diuretics may worsen electrocardiographic changes and/or hypokalemia associated with concomitant beta-agonists. Use with caution.

Source: NLP:budesonide and formoterol fumarate

Dextrose Injection can affect fluid and/or electrolyte balance; monitor blood glucose, fluid balance, serum electrolyte concentrations and acid-base balance when used with diuretics.

Source: NLP:dextrose monohydrate

Monitor for signs of worsening renal function and diuretic efficacy including antihypertensive effects.

Source: NLP:diclofenac

Monitor for worsening renal function and reduced diuretic efficacy including antihypertensive effects.

Source: NLP:diclofenac sodium, methyl salicylate

Coadministration with diuretics increases urine volume and frequency, enhancing potential for volume depletion. Monitor volume status and renal function.

Source: NLP:empagliflozin

Coadministration with empagliflozin increases urine volume and voids, enhancing potential for volume depletion.

Source: NLP:empagliflozin, metformin hydrochloride

Diuretics may cause excessive reduction of blood pressure after enalaprilat initiation. Close medical supervision recommended, especially if diuretic therapy recently instituted.

Source: NLP:enalaprilat

Counter pressor effects, increase arrhythmogenic potential, and potentiate hypokalemic effects of epinephrine.

Source: NLP:epinephrine in sodium chloride

Additional reductions in blood pressure may occur when epoprostenol is administered with diuretics.

Source: NLP:epoprostenol

Non-potassium-sparing diuretics may worsen electrocardiographic changes and hypokalemia when used with beta-agonists.

Source: NLP:fluticasone propionate and salmeterol xinafoate

May potentiate hypokalemia or ECG changes with formoterol. Use with caution.

Source: NLP:formoterol fumarate

Non-potassium-sparing diuretics may worsen electrocardiographic changes and hypokalemia with concomitant beta-agonists. Use with caution.

Source: NLP:budesonide and formoterol fumarate dihydrate

May reduce the glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Source: NLP:glimepiride

Tend to produce hyperglycemia and may lead to loss of control. Patient should be closely observed for loss of control when initiated or hypoglycemia when withdrawn.

Source: NLP:glipizide

May cause electrolyte imbalance; caution advised with haloperidol decanoate as hypokalemia, hypomagnesemia, and hypocalcemia increase QT prolongation risk.

Source: NLP:haloperidol decanoate

Hydrocodone may reduce the efficacy of diuretics. Monitor for reduced effect.

Source: NLP:hydrocodone bitartrate and homatropine methylbromide

Hydrocodone may reduce the efficacy of diuretics. Monitor for reduced effect.

Source: NLP:hydrocodone bitartrate and homatropine methylbromide oral solution

Hydrocodone may reduce the efficacy of diuretics. Monitor for reduced effect.

Source: NLP:hydrocodone polistirex and chlorpheniramine polistirex

Ibuprofen may reduce the effect of diuretics; diuretics can increase the risk of nephrotoxicity of NSAIDs in dehydrated patients. Monitor renal function.

Source: NLP:ibuprofen lysine

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart-szjj

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Source: NLP:insulin degludec

May decrease blood glucose lowering effect of insulin glargine; dosage increases and increased glucose monitoring may be required.

Source: NLP:insulin glargine

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin glulisine

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin human

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Source: NLP:insulin lispro

May decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.

Source: NLP:insulin lispro-aabc

Non-potassium-sparing diuretics may worsen ECG changes or hypokalemia when combined with beta-agonists, especially at higher doses. Consider monitoring potassium levels.

Source: NLP:levalbuterol

Non-potassium-sparing diuretics may have worsening ECG changes or hypokalemia when combined with beta-agonists. Monitor potassium levels during coadministration.

Source: NLP:levalbuterol hydrochloride

Non-potassium-sparing diuretics may worsen electrocardiographic changes and hypokalemia associated with levalbuterol. Consider monitoring potassium levels.

Source: NLP:levalbuterol tartrate

Opioids can reduce diuretic efficacy by inducing antidiuretic hormone release.

Source: NLP:levorphanol tartrate

Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations. Frequent monitoring and dosage adjustment recommended.

Source: NLP:lithium carbonate

Excessive reductions in blood pressure may occur when ACE inhibitors are started in patients on diuretic therapy. Risk can be minimized by discontinuing diuretics or cautiously increasing salt intake before initiation.

Source: NLP:moexipril hydrochloride

Non-potassium-sparing diuretics may potentiate hypokalemia and ECG changes from formoterol. Use with caution.

Source: NLP:mometasone furoate and formoterol fumarate dihydrate

Opioids can reduce efficacy of diuretics by inducing antidiuretic hormone release. Monitor for diminished diuresis and blood pressure effects.

Source: NLP:nalbuphine hydrochloride

Opioids can reduce diuretic efficacy by inducing antidiuretic hormone release. Monitor for diminished diuresis and blood pressure effects.

Source: NLP:pentazocine and naloxone

Concomitant use may increase risk of hyponatremia. Monitor serum sodium concentrations if use cannot be avoided.

Source: NLP:potassium chloride

May increase risk of hyponatremia. Monitor serum sodium concentrations if use cannot be avoided.

Source: NLP:sodium chloride and potassium chloride

Addition of a diuretic to prazosin causes additive hypotensive effect requiring dose adjustment and careful titration.

Source: NLP:prazosin hydrochloride

Potassium-depleting diuretics used with corticosteroids require close observation for hypokalemia development.

Source: NLP:prednisolone sodium phosphate

Codeine may reduce the efficacy of diuretics. Monitor for reduced effect.

Source: NLP:promethazine hydrochloride and codeine phosphate

Codeine may reduce the efficacy of diuretics. Monitor for reduced effect.

Source: NLP:promethazine, phenylephrine, codeine

Diuretics are associated with hyponatremia; concomitant use with 0.9% sodium chloride injection may increase risk of developing hyponatremia.

Source: NLP:sodium chloride

Diuretics may potentiate hypokalemia or ECG changes when used with olodaterol. Use with caution.

Source: NLP:tiotropium bromide and olodaterol

Diuretics can enhance aminoglycoside toxicity by altering serum and tissue concentrations and causing dehydration. Monitor renal function, serum electrolytes, and signs of ototoxicity.

Source: NLP:tobramycin sulfate

May cause excessive reduction of blood pressure after initiation of trandolapril therapy, especially with recently instituted diuretic therapy.

Source: NLP:trandolapril