Primidone Interactions

Methylphenidate may inhibit the metabolism of primidone. Downward dose adjustments may be required and plasma drug concentration should be monitored.

Source: NLP:dexmethylphenidate hydrochloride

Enzyme-inducing drug that can double valproate clearance. Increased monitoring of valproate and primidone concentrations and dosage adjustment indicated.

Source: NLP:divalproex sodium

Primidone administration causes folate deficiency through increased loss or metabolic interference.

Source: NLP:folic acid

Enzyme-inducing anti-epileptic drug that decreases imatinib AUC by 73%, significantly reducing imatinib exposure.

Source: NLP:imatinib

Primidone decreases lamotrigine concentrations by approximately 40%, requiring dose adjustment.

Source: NLP:lamotrigine

Acetazolamide decreases gastrointestinal absorption of primidone, reducing serum concentrations and potentially decreasing anticonvulsant effect.

Source: NLP:acetazolamide

Acetazolamide decreases gastrointestinal absorption of primidone, reducing serum concentrations and possibly decreasing anticonvulsant effect. Caution advised when beginning, discontinuing, or changing acetazolamide dose.

Source: NLP:acetazolamide extended-release

CYP3A4 inducer that decreases carbamazepine plasma levels. Carbamazepine levels and/or dosage adjustment may be necessary.

Source: NLP:carbamazepine

Higher dosage of eslicarbazepine acetate may be necessary. Primidone can induce enzymes that metabolize eslicarbazepine acetate and cause decreased plasma concentrations.

Source: NLP:eslicarbazepine acetate

CYP3A4 inducer that decreases ganaxolone exposure and efficacy; ZTALMY dosage may need to be increased but should not exceed maximum daily dosage.

Source: NLP:ganaxolone

CYP3A4 inducer may decrease serum hydrocortisone concentrations and increase risk of adrenal crisis; may require dose increase.

Source: NLP:hydrocortisone

Decreases lamotrigine concentration approximately 40%.

Source: NLP:lamotrigine er

Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible children.

Source: NLP:leucovorin calcium

Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. Monitor patients taking levoleucovorin with this drug.

Source: NLP:levoleucovorin

Metabolic enzyme inducer that may decrease plasma concentrations of ethinyl estradiol and levonorgestrel, potentially diminishing contraceptive effectiveness and increasing breakthrough bleeding.

Source: NLP:levonorgestrel and ethinyl estradiol

Methylphenidate may inhibit metabolism of this anticonvulsant. Downward dose adjustments may be required.

Source: NLP:methylphenidate

Methylphenidate may inhibit metabolism of primidone; downward dose adjustment may be required and plasma concentrations should be monitored.

Source: NLP:methylphenidate hydrochloride

Impairs folate absorption and increases metabolism of circulating folate.

Source: NLP:prenatal multivitamin tablet and combination omega-3 softgel/mineral capsule

Primidone decreases rufinamide concentration by 25-46%.

Source: NLP:rufinamide

Primidone increases tiagabine clearance by 60%, which may require dose adjustments to maintain therapeutic efficacy.

Source: NLP:tiagabine hydrochloride

Primidone is an enzyme-inducing drug that can increase valproate clearance and may double it. Monitoring of valproate and primidone concentrations and dosage adjustment are indicated.

Source: NLP:valproate sodium

Enzyme-inducing drug that can increase valproate clearance and double clearance rate. Increased monitoring of valproate and concomitant drug concentrations and dosage adjustment indicated.

Source: NLP:valproic acid

Levetiracetam does not influence primidone plasma concentration and primidone does not influence levetiracetam pharmacokinetics.

Source: NLP:levetiracetam