May increase methotrexate toxicity by displacing the drug from serum albumin binding.
Source: NLP:methotrexate
Phenylbutazone Interactions
17 interactions on record
May reduce contraceptive effectiveness and result in unintended pregnancy or breakthrough bleeding by increasing metabolism of contraceptive steroids.
Source: NLP:norethindrone
Cholestyramine may delay or reduce the absorption of phenylbutazone.
Source: NLP:cholestyramine
Cholestyramine may delay or reduce the absorption of phenylbutazone.
Source: NLP:cholestyramine powder for suspension
Cholestyramine may delay or reduce absorption of phenylbutazone.
Source: NLP:choleystyramine light
Similar association with reduced efficacy and breakthrough bleeding suggested, though less marked than with rifampin.
Source: NLP:desogestrel and ethinyl estradiol and ethinyl estradiol
Similar association with reduced efficacy, though less marked than rifampin.
Source: NLP:ethynodiol diacetate and ethinyl estradiol
Phenylbutazone + EtodolacModerate
Phenylbutazone increases the free fraction of etodolac by approximately 80%. Coadministration is not recommended.
Source: NLP:etodolac
Phenylbutazone + Heparin SodiumModerate
Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or heparin recommended.
Source: NLP:heparin sodium
Metabolic enzyme inducer that may decrease plasma concentrations of ethinyl estradiol and levonorgestrel, potentially diminishing contraceptive effectiveness and increasing breakthrough bleeding.
Source: NLP:levonorgestrel and ethinyl estradiol
Phenylbutazone may reduce contraceptive effectiveness and increase incidence of breakthrough bleeding.
Source: NLP:norethindrone acetate and ethinyl estradiol and ferrous fumarate
Reduction in contraceptive effectiveness and increased incidence of breakthrough bleeding have been suggested.
Source: NLP:norethindrone acetate and ethinyl estradiol
Phenylbutazone + Penicillin GModerate
Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
Source: NLP:penicillin g
Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Source: NLP:penicillin g potassium
Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Source: NLP:penicillin g sodium
Salicylate inhibits the uricosuric effect of phenylbutazone.
Source: NLP:salicylic acid 10%
Administered without adverse drug interaction in limited clinical experience.
Source: NLP:prazosin hydrochloride