Concentration of fluorouracil is increased and toxicity may be enhanced. Deaths from severe enterocolitis, diarrhea, and dehydration reported in elderly patients.
Source: NLP:capecitabine
Leucovorin Interactions
2 interactions on record
Co-administration with 5-FU reduces SN-38 Cmax by 14% and AUC by 8%. This sequence is recommended in combination trials.
Source: NLP:irinotecan hydrochloride