Aluminum Hydroxide Interactions

High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.

Source: NLP:cefpodoxime proxetil

Antacids containing aluminum impair absorption of tetracyclines.

Source: NLP:doxycycline hyclate

Aluminum hydroxide reduces ethambutol oral absorption, decreasing serum concentrations by ~20% and urinary excretion by ~13%. Separate administration by at least 4 hours.

Source: NLP:ethambutol hydrochloride

Antacid reduces serum levels and urinary excretion of fosinoprilat. Separate dosing by 2 hours if concomitant use is needed.

Source: NLP:fosinopril

Reduces serum levels and urinary excretion of fosinoprilat. Dosing should be separated by 2 hours.

Source: NLP:fosinopirl sodium

Antacid may impair absorption of fosinopril; dosing should be separated by 2 hours if concomitant use is necessary.

Source: NLP:fosinopril sodium and hydrochlorothiazide

Antacid containing aluminum hydroxide and magnesium hydroxide reduced gabapentin immediate release bioavailability by approximately 20%, but only 5% when taken 2 hours after antacids.

Source: NLP:gabapentin

Reduces gastric acidity and impairs ketoconazole absorption from tablets. Should be administered at least 1 hour before or 2 hours after ketoconazole.

Source: NLP:ketoconazole

Antacid that may affect intragastric pH and reduce levothyroxine absorption. Monitor patients appropriately.

Source: NLP:levothyroxine sodium

Decreases concentrations of mycophenolic acid; concomitant use is not recommended.

Source: NLP:mycophenolic acid

Decreases mycophenolate mofetil systemic exposure and may reduce efficacy. Administer at least 2 hours after mycophenolate mofetil.

Source: NLP:mycophenolate mofetil

Concomitant administration can delay the absorption of naproxen.

Source: NLP:naproxen

May decrease phenytoin serum levels by affecting absorption; should not be taken at the same time of day.

Source: NLP:extended phenytoin sodium

Separate administration by at least 1 hour.

Source: NLP:riociguat