Alcohol Interactions

186 interactions on record

Alcohol + FentanylContraindicated

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with fentanyl.

Source: NLP:fentanyl

CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when combined with fentanyl.

Source: NLP:fentanyl citrate

CNS depressant; concomitant use can increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:fentanyl transdermal

Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:hydrocodone bitartrate and acetaminophen

Concomitant use may result in profound sedation, respiratory depression, coma, or death.

Source: NLP:ketamine hydrochloride

Alcohol + OxycodoneContraindicated

CNS depressant that when combined with oxycodone increases risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:oxycodone

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with oxycodone and acetaminophen.

Source: NLP:oxycodone and acetaminophen

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with oxycodone.

Source: NLP:oxycodone hydrochloride

Alcohol + RamelteonContraindicated

Causes additive psychomotor impairment. Should not be used in combination with ramelteon.

Source: NLP:ramelteon

Sodium oxybate oral solution is contraindicated for use in combination with alcohol due to potentiation of CNS-depressant effects.

Source: NLP:sodium oxybate

Alcohol + TopiramateContraindicated

Alcohol use is contraindicated within 6 hours prior to and 6 hours after TROKENDI XR administration due to CNS depression risk.

Source: NLP:topiramate

Concurrent ingestion of acitretin and ethanol leads to formation of etretinate, a retinoid with much longer half-life and potential for prolonged effects and teratogenicity.

Source: NLP:acitretin

Produces additive CNS depressant effects when co-administered with alprazolam.

Source: NLP:alprazolam

Concomitant administration of high or low dose ethanol with apomorphine hydrochloride causes greater decreases in blood pressure compared to apomorphine alone.

Source: NLP:apomorphine hydrochloride

CNS depressant increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with benzodiazepines or other CNS depressants.

Source: NLP:benzhydrocodone and acetaminophen

CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.

Source: NLP:buprenorphine

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:buprenorphine and naloxone

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:buprenorphine hcl

Additive CNS depressant effects increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:butorphanol tartrate

Alcohol causes additive CNS depressant effects with carbinoxamine. Avoid concomitant use.

Source: NLP:carbinoxamine maleate

CNS-depressant action of clonazepam may be potentiated by alcohol, increasing risk of sedation and respiratory depression.

Source: NLP:clonazepam

Concomitant use not recommended due to enhancement of sedative effect.

Source: NLP:diazepam

Concomitant use with alcohol should be avoided due to risk of additive CNS depression and other adverse effects.

Source: NLP:doxepin hydrochloride

Additive effect on psychomotor performance when coadministered with eszopiclone.

Source: NLP:eszopiclone

Nausea, vomiting, flushing, tachycardia, and severe hypotension have been reported following alcohol ingestion during griseofulvin therapy.

Source: NLP:griseofulvin

Additive CNS depressant effects can increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:hydromorphone hydrochloride

CNS depressant with additive effects increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:levorphanol tartrate

Produces increased CNS-depressant effects including respiratory depression and sedation.

Source: NLP:lorazepam

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:methadone hydrochloride

CNS depressant increases risk of CNS depression. Avoid concomitant use or monitor for adverse reactions.

Source: NLP:metoclopramide

Concomitant use can increase morphine plasma levels and potentially cause fatal overdose. Additive CNS depression increases risk of respiratory depression, coma, and death.

Source: NLP:morphine sulfate

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:nalbuphine hydrochloride

Additive depressant effects with phenobarbital; toxic effects and fatalities have occurred with this combination.

Source: NLP:phenobarbital

Concomitant use of alcohol with phenobarbital may produce additive central nervous system depressant effects.

Source: NLP:phenobarbital sodium

Potentiates cognitive and motor effects of quetiapine. Alcoholic beverages should be limited while taking quetiapine.

Source: NLP:quetiapine

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with remifentanil.

Source: NLP:remifentanil hydrochloride

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Either scopolamine or the interacting drug should be chosen depending on importance.

Source: NLP:scopolamine

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when combined with sufentanil.

Source: NLP:sufentanil

May increase the rate of tacrolimus release and increase risk of serious adverse reactions including neurotoxicity and QT prolongation.

Source: NLP:tacrolimus

Substantial consumption (5+ units) with tadalafil increases potential for orthostatic signs and symptoms including increased heart rate, decreased standing blood pressure, dizziness, and headache.

Source: NLP:tadalafil

CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.

Source: NLP:tapentadol hydrochloride

Produces additive CNS-depressant effects when co-administered with temazepam.

Source: NLP:temazepam

Increases drug levels in bloodstream and increases adverse reactions. CNS depressant effects are additive.

Source: NLP:tizanidine

Alcohol increases tizanidine bloodstream concentration and adverse reactions; CNS depressant effects are additive.

Source: NLP:tizanidine hydrochloride

Alcohol increases overall amount of tizanidine in bloodstream and CNS depressant effects are additive, resulting in increased adverse reactions.

Source: NLP:tizanidne hydrochloride

Additive adverse effect on psychomotor performance and increased risk of CNS depression, drowsiness, and impaired driving ability.

Source: NLP:zolpidem tartrate

Ethanol has complex effects on acetaminophen metabolism; excessive alcohol can induce hepatic cytochromes increasing hepatotoxic potential, while also acting as competitive inhibitor of acetaminophen metabolism.

Source: NLP:acetaminophen

Can potentiate the effect of metformin on lactate metabolism, increasing lactic acidosis risk. Patients should avoid excessive alcohol intake.

Source: NLP:alogliptin and metformin hydrochloride

Possibility of additive or potentiating effect with CNS depressants.

Source: NLP:apraclonidine

Substantial alcohol consumption (>3 units) with avanafil increases orthostatic signs and symptoms including increased heart rate, decreased standing blood pressure, dizziness, and headache.

Source: NLP:avanafil

Concurrent use with azelastine may cause reductions in alertness and impairment of central nervous system performance; concurrent use should be avoided.

Source: NLP:azelastine

Concurrent use may cause reductions in alertness and impairment of central nervous system performance; should be avoided.

Source: NLP:azelastine hydrochloride

Additive CNS depression including drowsiness and sedation when used concomitantly with baclofen oral suspension.

Source: NLP:baclofen

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Source: NLP:brimonidine

CNS depressant with potential for additive or potentiating effect when used with brimonidine tartrate ophthalmic solution.

Source: NLP:brimonidine tartrate

Additive sedative effects with carisoprodol. Caution should be exercised when used concomitantly.

Source: NLP:carisoprodol

Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide.

Source: NLP:chlorothiazide

Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide sodium.

Source: NLP:chlorothiazide sodium

Use of alcohol by depressed patients taking citalopram is not recommended despite lack of potentiation in cognitive and motor effects in clinical trials.

Source: NLP:citalopram

Use not recommended in depressed patients taking citalopram, consistent with other psychotropic medications, despite lack of potentiation in clinical trials.

Source: NLP:citalopram hydrobromide

Increases clobazam blood levels by approximately 50% and increases risk of sedation and somnolence when used concomitantly.

Source: NLP:clobazam

Clonidine may potentiate the CNS-depressive effects of alcohol.

Source: NLP:clonidine

Cyclobenzaprine may enhance the effects of alcohol and CNS depression.

Source: NLP:cyclobenzaprine

Patients should be warned that response to alcoholic beverages may be exaggerated while taking desipramine.

Source: NLP:desipramine hydrochloride

Sedative effects of alcohol may be potentiated when taken with doxepin.

Source: NLP:doxepin

Use of alcohol by patients taking escitalopram is not recommended, although escitalopram did not potentiate cognitive and motor effects in clinical trials.

Source: NLP:escitalopram

Use is not recommended with escitalopram despite lack of potentiation in clinical trials, consistent with other psychotropic medications.

Source: NLP:escitalopram oxalate

CNS depressant that may potentiate the action of estazolam and increase risk of respiratory depression and sedation.

Source: NLP:estazolam

Fomepizole reduces ethanol elimination by ~40%; ethanol reduces fomepizole elimination by ~50% through alcohol dehydrogenase inhibition. Monitor concomitant use.

Source: NLP:fomepizole

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:fosphenytoin sodium

CNS depressant that may increase risk of somnolence and sedation when used concomitantly with ganaxolone.

Source: NLP:ganaxolone

Both acute and chronic alcohol intake may potentiate or weaken the glucose-lowering action of glimepiride in an unpredictable fashion.

Source: NLP:glimepiride

May lead to either potentiation or weakening of glucose-lowering effect; increased monitoring required.

Source: NLP:glipizide

CNS depressant that may be potentiated by haloperidol decanoate; monitor for combined CNS depression effects.

Source: NLP:haloperidol decanoate

CNS depressant that haloperidol may potentiate, increasing risk of enhanced CNS depression.

Source: NLP:haloperidol lactate

May increase or decrease the blood glucose lowering effect. Dose adjustment and increased glucose monitoring required.

Source: NLP:insulin aspart

May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart-szjj

May increase or decrease blood glucose lowering effect. Dosage adjustment and increased glucose monitoring may be required.

Source: NLP:insulin degludec

May increase or decrease blood glucose lowering effect; dosage adjustment and increased glucose monitoring may be required.

Source: NLP:insulin glargine

May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin glulisine

May increase or decrease blood glucose lowering effect; dose adjustment and glucose monitoring may be required.

Source: NLP:insulin human

May increase or decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Source: NLP:insulin lispro

May increase or decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin lispro-aabc

Alcohol exhibits additive vasodilating effects with isosorbide mononitrate, potentially causing additive hypotensive effects.

Source: NLP:isosorbide mononitrate

Concomitant use may enhance CNS depression and cognitive/neuropsychiatric effects; use with caution.

Source: NLP:lasmiditan

Alcohol potentiates the effect of metformin on lactate metabolism, increasing lactic acidosis risk. Patients should avoid excessive alcohol intake.

Source: NLP:linagliptin and metformin hydrochloride

Substantial consumption (5+ units) combined with OPSYNVI increases potential for orthostatic signs and symptoms including dizziness and headache.

Source: NLP:macitentan and tadalafil

Coadministration may result in increased CNS depression when used concurrently with meclizine.

Source: NLP:meclizine

Sedative effects of metaxalone and alcohol may be additive. Exercise caution and monitor for respiratory depression and sedation.

Source: NLP:metaxalone

Potentiates metformin's effect on lactate metabolism, increasing lactic acidosis risk with excessive intake.

Source: NLP:metformin

Potentiates the effect of metformin on lactate metabolism. Warn patients against excessive alcohol intake.

Source: NLP:metformin er 500 mg

Potentiates metformin's effect on lactate metabolism, increasing risk for lactic acidosis with excessive intake.

Source: NLP:metformin hydrochloride tablet

Hypotensive effects may be potentiated by volume contraction associated with metolazone therapy.

Source: NLP:metolazone

Concomitant use increases impairment of cognitive and motor skills. Avoid concomitant use.

Source: NLP:mirtazapine

Additive CNS depressant effects; increases positive subjective mood effects. Caution must be used when administering nabilone in combination with CNS depressants.

Source: NLP:nabilone

May increase blood-glucose-lowering effect and susceptibility to hypoglycemia. Dose reductions and increased glucose monitoring may be required.

Source: NLP:nateglinide

Nefazodone did not potentiate cognitive and psychomotor effects in normal subjects, but concomitant use not advised in depressed patients.

Source: NLP:nefazodone hydrochloride

Concomitant alcohol may increase side effects of flushing and pruritus and should be avoided at time of drug ingestion.

Source: NLP:niacin

Co-administration potentiates orthostatic hypotension observed with olanzapine.

Source: NLP:olanzapine

CNS effects; use caution in combination and avoid alcohol.

Source: NLP:paliperidone

Concomitant use increases CNS depression with additive or supra-additive effects on driving ability, vigilance, alertness, and increased anger, confusion, and depression.

Source: NLP:perampanel

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:extended phenytoin sodium

Potentiates metformin effect on lactate metabolism, increasing lactic acidosis risk. Patients should be warned against excessive alcohol intake.

Source: NLP:pioglitazone hydrochloride and metformin hydrochloride

Additive effects on cognitive and gross motor functioning observed when co-administered with pregabalin.

Source: NLP:pregabalin

Promethazine may increase, prolong, or intensify the sedative action of alcohol; avoid or use reduced dosage.

Source: NLP:promethazine hydrochloride

Hepatic enzyme inducer that decreases blood levels of propranolol by increasing hepatic metabolism.

Source: NLP:propranolol hydrochloride

Quetiapine potentiates cognitive and motor effects of alcohol; alcoholic beverages should be limited.

Source: NLP:quetiapine fumarate

Caution should be used due to additive CNS effects when alcohol is administered with risperidone.

Source: NLP:risperidone

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Monitor patients or consider choosing one drug over the other.

Source: NLP:scolopamine transdermal system

Co-administration of sildenafil 50 mg with alcohol studied; interaction mentioned but full severity details cut off in provided text.

Source: NLP:sildenafil

Concomitant use of DIACOMIT with alcohol may increase the risk of sedation and somnolence.

Source: NLP:stiripentol

Additive psychomotor impairment demonstrated when co-administered with suvorexant.

Source: NLP:suvorexant

Concomitant use may have additive effects and worsen sedation and somnolence.

Source: NLP:tetrabenazine

A single large dose of alcohol decreases theophylline clearance for up to 24 hours, resulting in approximately 30% increase in serum concentration.

Source: NLP:theophylline

Alcoholic beverages should be avoided during tinidazole therapy and for 3 days after because abdominal cramps, nausea, vomiting, headaches, and flushing may occur.

Source: NLP:tinidazole

Alcohol increases the release rate of tiopronin from VENXXIVA formulation; risk of adverse events is unknown. Avoid alcohol consumption 2 hours before and 3 hours after taking VENXXIVA.

Source: NLP:tiopronin

Concomitant use of alcoholic beverages may be associated with exaggerated effects of trimipramine maleate.

Source: NLP:trimipramine maleate

Alcohol increases the release rate of Venlafaxine Extended-Release Tablets. Concomitant use should be avoided.

Source: NLP:venlafaxine

Compounds that quench active oxygen species or scavenge radicals would be expected to decrease VISUDYNE activity.

Source: NLP:verteporfin for injection

Zaleplon potentiated CNS-impairing effects of ethanol on balance testing, reaction time, and divided attention for up to 2.5 hours. Pharmacodynamic interaction without altered ethanol pharmacokinetics.

Source: NLP:zaleplon

Concomitant use may increase CNS depression and cognitive/neuropsychiatric adverse events. Use with caution.

Source: NLP:zonisamide

No disulfiram-like reactions were reported in a study of 22 healthy volunteers administered cefotaxime and ethanol.

Source: NLP:cefotaxime

Alcohol consumed 30 minutes prior to sumatriptan ingestion had no effect on the pharmacokinetics of sumatriptan.

Source: NLP:sumatriptan succinate, camphor, menthol

Acamprosate does not affect the pharmacokinetics of alcohol, and the pharmacokinetics of acamprosate are not affected by alcohol.

Source: NLP:acamprosate calcium