Phenothiazines Interactions

Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; may result in further lowering of blood pressure.

Source: NLP:adrenalin (epinephrine)

Cabergoline should not be administered concurrently with phenothiazines, which are D2-antagonists that may antagonize cabergoline's dopaminergic effects.

Source: NLP:cabergoline

Do not use epinephrine to counteract circulatory collapse from phenothiazines; reversal of pressor effects may cause further blood pressure lowering.

Source: NLP:epinephrine

Potentiate CNS-depressant action of clonazepam.

Source: NLP:clonazepam

Actions of benzodiazepines may be potentiated by phenothiazines.

Source: NLP:clorazepate dipotassium

Should be avoided due to risk of QT prolongation and torsades de pointes.

Source: NLP:foscarnet sodium

May produce severe prolonged hypotension or hypertension. Concurrent use should generally be avoided; careful monitoring essential if necessary.

Source: NLP:lidocaine hydrochloride and epinephrine bitartrate

Additive depression of the central nervous system when administered with lorazepam injection.

Source: NLP:lorazepam

Substrates for P450 2D6 that inhibit the enzyme, potentially increasing nortriptyline plasma concentrations to toxic levels.

Source: NLP:nortriptyline hydrochloride

May produce severe, prolonged hypotension or hypertension; concurrent use should generally be avoided.

Source: NLP:prilocaine hcl and epinephrine

Phenothiazines produce hyperglycemia and may lead to loss of blood glucose control in patients receiving Acarbose. Close observation for loss of glucose control is recommended.

Source: NLP:acarbose

Concomitant use may enhance phototoxic reaction to photodynamic therapy.

Source: NLP:aminolevulinic acid hydrochloride

May reduce or reverse the pressor effect of epinephrine; concurrent use should be avoided but careful monitoring is essential if necessary.

Source: NLP:articaine hydrochloride and epinephrine

May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary requires careful patient monitoring.

Source: NLP:articaine hydrochloride, epinephrine bitartrate

Phenothiazines are dopamine antagonists that result in decreased efficacy of bromocriptine mesylate.

Source: NLP:bromocriptine mesylate

May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions.

Source: NLP:bupivacaine hydrochloride

May reduce or reverse the pressor effect of epinephrine. Concurrent use should generally be avoided; if necessary, careful patient monitoring is essential.

Source: NLP:bupivacaine hydrochloride and epinephrine bitartrate

Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed for loss of therapeutic response.

Source: NLP:carbidopa

Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed for loss of response.

Source: NLP:carbidopa and levodopa

Dopamine D2 receptor antagonists may reduce therapeutic effects of levodopa.

Source: NLP:carbidopa, levodopa and entacapone

Substrates for P450 2D6 that inhibit the enzyme and may increase clomipramine plasma concentrations.

Source: NLP:clomipramine hydrochloride

Inhibit P450 2D6 and are substrates for the enzyme; may increase desipramine concentrations; dose adjustment and monitoring recommended.

Source: NLP:desipramine hydrochloride

May potentiate or be potentiated by diazepam action. Careful consideration should be given when combining.

Source: NLP:diazepam

Antipsychotic agents may increase certain actions or side effects of dicyclomine hydrochloride.

Source: NLP:dicyclomine hydrochloride

Concurrent use may antagonize the anorectic effect of diethylpropion.

Source: NLP:diethylpropion hydrochloride

Suppress dopaminergic renal and mesenteric vasodilation induced by low-dose dopamine.

Source: NLP:dopamine hydrochloride

May produce hyperglycemia and lead to loss of glycemic control; monitor closely.

Source: NLP:empagliflozin, metformin hydrochloride

May potentiate the action of estazolam; careful consideration of CNS effects needed.

Source: NLP:estazolam

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:fosphenytoin sodium

Phenothiazines may produce hyperglycemia and lead to loss of control of glyburide. Patients should be closely observed for loss of control.

Source: NLP:glyburide

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Source: NLP:glimepiride

Phenothiazines may produce hyperglycemia and lead to loss of glycemic control. Patient should be observed closely for loss of control when initiated or withdrawn.

Source: NLP:glipizide

Concurrent use may intensify antimuscarinic effects and increase anticholinergic side effects.

Source: NLP:glycopyrrolate

Additive CNS depressant effects; reduced dosage of hydromorphone recommended to avoid excessive effects.

Source: NLP:hydromorphone hydrochloride

Additive adverse effects from cholinergic blockade may occur when combined with hyoscyamine sulfate.

Source: NLP:hyoscyamine sulfate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart-szjj

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Source: NLP:insulin degludec

May decrease blood glucose lowering effect of insulin glargine; dosage increases and increased glucose monitoring may be required.

Source: NLP:insulin glargine

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin human

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Source: NLP:insulin lispro

May decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.

Source: NLP:insulin lispro-aabc

May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoided.

Source: NLP:lidocaine hydrochloride

Phenothiazines may produce hyperglycemia and lead to loss of glycemic control. Close monitoring of glycemic control is recommended.

Source: NLP:linagliptin and metformin hydrochloride

Phenothiazines may reduce or reverse the pressor effect of epinephrine. Concurrent use should generally be avoided.

Source: NLP:lidocaine, kenalog, povidone iodine

May reduce or reverse the pressor effect of epinephrine in mepivacaine solutions.

Source: NLP:mepivacaine hydrochloride

Produce hyperglycemia and may lead to loss of glycemic control when used with metformin.

Source: NLP:metformin

May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose control.

Source: NLP:metformin er 500 mg

Drugs that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Source: NLP:metformin hydrochloride

May produce hyperglycemia and lead to loss of glycemic control during metformin therapy; monitor blood glucose.

Source: NLP:metformin hydrochloride extended-release tablets

May produce hyperglycemia and lead to loss of glycemic control when used with metformin.

Source: NLP:metformin hydrochloride tablet

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:extended phenytoin sodium

Concomitant use may increase the risk of photosensitivity reaction. Avoid concomitant use with other photosensitizing agents.

Source: NLP:porfimer sodium

Dopamine antagonists may diminish the effectiveness of pramipexole dihydrochloride.

Source: NLP:pramipexole dihydrochloride

Neuroleptic dopamine antagonist that may reduce the efficacy of ropinirole extended-release tablets.

Source: NLP:ropinirole

Neuroleptic dopamine antagonists that may reduce the efficacy of ropinirole tablets.

Source: NLP:ropinirole hydrochloride

May produce hyperglycemia and lead to loss of glycemic control. Monitor blood glucose closely during concomitant use.

Source: NLP:sitagliptin and metformin hydrochloride

May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions. Concurrent use should generally be avoided.

Source: NLP:bupivacaine hydrochloride, lidocaine hydrochloride, triamcinolone acetonide, povidine iodine

Other photosensitizing agents that could increase the potential for skin photosensitivity reactions.

Source: NLP:verteporfin for injection

Antipsychotic drug phenothiazines interact with benztropine; interaction details referenced in WARNINGS section.

Source: NLP:benztropine

Antipsychotic drug with potential interaction; specific severity not detailed in provided text.

Source: NLP:benztropine mesylate