Macrolide Antibiotics Interactions

CYP 3A4 inhibitors increase dihydroergotamine exposure; contraindicated per prescribing information.

Source: NLP:dihydroergotamine mesylate

Patients receiving antibiotics generally should not be treated with Mecamylamine HCl (ganglion blocker).

Source: NLP:mecamylamine hydrochloride

Macrolide antibiotics cause significant decrease in corticosteroid clearance, potentially increasing corticosteroid effects.

Source: NLP:betamethasone acetate and betamethasone sodium phosphate

Parenteral bumetanide use with aminoglycosides should be avoided due to ototoxic potential, especially with impaired renal function, except in life-threatening conditions.

Source: NLP:bumetanide

Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.

Source: NLP:cefoxitin

Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.

Source: NLP:cefoxitin sodium

Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics.

Source: NLP:cefprozil

Ethacrynate sodium may increase ototoxic potential of aminoglycosides. Concurrent use should be avoided.

Source: NLP:ethacrynate sodium

Ethacrynic acid may increase the ototoxic potential of aminoglycoside antibiotics; concurrent use should be avoided.

Source: NLP:ethacrynic acid

Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.

Source: NLP:furosemide

Oral quinolone antibiotics may have reduced absorption when co-administered with lanthanum carbonate. Separate dosing by at least 1 hour before or 4 hours after.

Source: NLP:lanthanum carbonate

Oral or intravenous sulfonamides may increase methotrexate plasma concentrations and are highly protein-bound, increasing risk of severe adverse reactions.

Source: NLP:methotrexate

Should be used cautiously or avoided during pyridostigmine treatment due to interference with neuromuscular transmission.

Source: NLP:pyridostigmine bromide

Loop diuretics increase ototoxic potential; avoid concomitant use with torsemide if possible.

Source: NLP:torsemide

Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Source: NLP:triamcinolone acetonide

Moderate CYP1A2 inhibitors. Concomitant administration with alosetron should be avoided unless clinically necessary due to potential drug interactions.

Source: NLP:alosetron hydrochloride

Strong CYP3A4 inhibitors like azole antimycotics may increase bromocriptine plasma levels; caution advised when co-administering.

Source: NLP:bromocriptine mesylate

May prolong neuromuscular blockade action of cisatracurium besylate. Use peripheral nerve stimulator and monitor clinical signs.

Source: NLP:cisatracurium besylate

Potent CYP3A4 inhibitors expected to decrease clearance of citalopram.

Source: NLP:citalopram hydrobromide

Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Source: NLP:depo-medrol, lidocaine, isopropyl alcohol

May cause significant decrease in dexamethasone clearance.

Source: NLP:dexamethasone

Macrolide antibiotics cause significant decrease in dexamethasone clearance, increasing corticosteroid levels.

Source: NLP:dexamethasone 1.5 mg

Macrolide antibiotics cause significant decrease in dexamethasone clearance.

Source: NLP:dexamethasone intensol

Carbapenem antibiotics may affect valproate clearance. Monitoring of valproate concentrations is recommended.

Source: NLP:divalproex sodium

Zinc can inhibit the absorption of certain antibiotics; take at least 2 hours apart to minimize interactions.

Source: NLP:doconexent, niacinamide, .alpha.-tocopherol acetate, dl-, cholecalciferol, beta carotene, ascorbic acid, thiamine mononitrate, riboflavin, pyridoxine hydrochloride, cyanocobalamin, iron, zinc oxide, cupric oxide, potassium iodide, magnesium oxide, folic acid, and levomefolate calcium

Some macrolide antibiotics are significant CYP3A inhibitors; estazolam should be used with caution and appropriate dosage reduction may be needed.

Source: NLP:estazolam

May increase the glucose-lowering effect of glipizide, increasing susceptibility to hypoglycemia. Monitor closely.

Source: NLP:glipizide

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin aspart-szjj

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Source: NLP:insulin degludec

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Source: NLP:insulin glargine

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin glulisine

May increase risk of hypoglycemia; dose adjustment and increased glucose monitoring may be required.

Source: NLP:insulin human

May increase risk of hypoglycemia. Dose reductions and increased glucose monitoring may be required.

Source: NLP:insulin lispro-aabc

Macrolide antibiotics cause significant decrease in corticosteroid clearance with methylprednisolone acetate.

Source: NLP:methylprednisolone acetate, bupivacaine hydrochloride, povidone-iodine

Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance.

Source: NLP:lidocaine, kenalog, povidone iodine

Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid effects.

Source: NLP:methylprednisolone acetate

Macrolide antibiotics cause a significant decrease in corticosteroid clearance.

Source: NLP:methylprednisolone sodium succinate

Macrolide antibiotics inhibit corticosteroid metabolism, potentially increasing corticosteroid effects.

Source: NLP:prednisolone sodium phosphate

Macrolide antibiotics cause significant decrease in corticosteroid clearance, potentially increasing prednisone levels.

Source: NLP:prednisone

May decrease the absorption of vitamin B12.

Source: NLP:prenatal multivitamin tablet and combination omega-3 softgel/mineral capsule

Sodium sulfate, potassium sulfate, and magnesium sulfate oral solution can reduce absorption of fluoroquinolone antibiotics via chelation with magnesium. Administer at least 2 hours before and not less than 6 hours after this product.

Source: NLP:sodium sulfate anhydrous, potassium sulfate, and magnesium sulfate

Administer at least 2 hours before and not less than 6 hours after SUPREP to avoid chelation with magnesium and reduced absorption.

Source: NLP:sodium sulfate, potassium sulfate, magnesium sulfate

Sucralfate reduces the bioavailability of fluoroquinolone antibiotics. Dosing 2 hours before sucralfate eliminates the interaction.

Source: NLP:sucralfate

Macrolide antibiotics cause a significant decrease in corticosteroid clearance.

Source: NLP:triamcinolone acetonide extended-release injectable suspension

Reports of pregnancy with hormonal contraceptives and antibiotics exist, but clinical studies have not shown consistent effects on synthetic steroid concentrations.

Source: NLP:medroxyprogesterone acetate

Reports of pregnancy while taking hormonal contraceptives and antibiotics, though clinical studies have not shown consistent effects on plasma concentrations.

Source: NLP:drospirenone and ethinyl estradiol

Clinical studies of interactions with antibiotics have not been conducted; potential interaction unknown.

Source: NLP:ribavirin