Clomipramine Interactions

Methylphenidate may inhibit the metabolism of clomipramine. Downward dose adjustments may be required and plasma drug concentration should be monitored.

Source: NLP:dexmethylphenidate hydrochloride

Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.

Source: NLP:methylene blue

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Elimination of clomipramine may be prolonged by armodafinil via inhibition of metabolic enzymes, resulting in higher systemic exposure. Dose reduction may be required.

Source: NLP:armodafinil

Methylphenidate may inhibit metabolism of this tricyclic drug. Downward dose adjustments may be required and plasma concentrations should be monitored.

Source: NLP:methylphenidate

Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.

Source: NLP:metoprolol

Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.

Source: NLP:metoprolol tartrate

Drug-drug interaction study showed increase in euphoria and postural hypotension in patients who switched to SAVELLA.

Source: NLP:milnacipran hydrochloride

Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when used concomitantly.

Source: NLP:modafinil