Statins Interactions

Increased risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4. Limit simvastatin to 10 mg daily and diltiazem to 240 mg.

Source: NLP:diltiazem hydrochloride

Fibrates may cause myopathy when given alone. Risk of myopathy and rhabdomyolysis is increased with concomitant use of fibrates with statins.

Source: NLP:fenofibrate

Fibrates may increase risk of myopathy and rhabdomyolysis when used concomitantly with statins. Monitor patients for signs and symptoms of myopathy during initiation and dosage titration.

Source: NLP:fenofibric acid

Caution should be used when prescribing niacin with statins as these agents can increase risk of myopathy/rhabdomyolysis.

Source: NLP:niacin

Lanthanum carbonate may reduce bioavailability of statins. Do not administer within 2 hours of lanthanum carbonate dosing.

Source: NLP:lanthanum carbonate