Antacids Containing Calcium Interactions

Avoid concomitant use. If unavoidable, modify KOMZIFTI administration time to separate dosing.

Source: NLP:ziftomenib

Antacids interfere with absorption of alendronate sodium. Patients should wait at least one-half hour after taking alendronate sodium before taking antacids.

Source: NLP:alendronate sodium

Decreased absorption of the triple therapy capsules; do not take concomitantly.

Source: NLP:bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

Decrease cabotegravir concentration; administer antacid products separately.

Source: NLP:cabotegravir sodium

Short-acting antacids may reduce gastric acidity and lower bioavailability of cefuroxime axetil. Administer cefuroxime axetil at least 1 hour before or 2 hours after antacids.

Source: NLP:cefuroxime axetil

Antacids can reduce absorption of chloroquine; an interval of at least 4 hours between intake should be observed.

Source: NLP:chloroquine phosphate

Avoid simultaneous administration. Administer at least 2 hours before or after dasatinib dose to prevent decreased concentrations.

Source: NLP:dasatinib

Coadministration of antacids could alter the release of dexmethylphenidate due to pH-dependent modified release characteristics.

Source: NLP:dexmethylphenidate hydrochloride

Antacids may interfere with the absorption of dicyclomine hydrochloride; simultaneous use should be avoided.

Source: NLP:dicyclomine hydrochloride

Concomitant administration may reduce plasma levels of diflunisal, with clinically significant effects when antacids are used on a continuous schedule.

Source: NLP:diflunisal

Decrease digoxin concentrations. Requires monitoring and dose adjustment.

Source: NLP:digoxin

Antacids containing calcium impair the absorption of tetracyclines.

Source: NLP:doxycycline

Antacids containing calcium impair absorption of tetracyclines.

Source: NLP:doxycycline hyclate

Antacids impair gastrointestinal folate uptake through pH elevation.

Source: NLP:folic acid

Elevates gastric pH and may reduce gefitinib plasma concentrations. Separate gefitinib dosing by 6 hours before or after administration.

Source: NLP:gefitinib

Antacids can reduce absorption of chloroquine; an interval of at least 4 hours between intake is recommended.

Source: NLP:hydroxychloroquine sulfate

Absorption of antacids may be decreased during concurrent use due to decreased gastrointestinal motility and delayed gastric emptying.

Source: NLP:hyoscyamine sulfate

Antacids interfere with absorption of ibandronate. Patients should take ibandronate at least 60 minutes before antacids.

Source: NLP:ibandronate sodium

Nonabsorbable antacids may inhibit the lactulose-induced drop in colonic pH, potentially reducing treatment efficacy. Monitor for lack of desired effect.

Source: NLP:lactulose

Magnesium or aluminum-containing antacids decrease levofloxacin absorption if taken within 2 hours. Separate dosing by at least 2 hours.

Source: NLP:levofloxacin

May form an insoluble chelate with levothyroxine, binding and delaying or preventing absorption, potentially resulting in hypothyroidism.

Source: NLP:levothyroxine sodium

Antacids may interfere with dissolution of mesalamine extended-release capsule coating due to pH effects; avoid co-administration.

Source: NLP:mesalamine

May reduce absorption of hyoscyamine and cause urine alkalinity, reducing methenamine effectiveness. Doses should be spaced 1 hour apart.

Source: NLP:methenamine, sodium phosphate, monobasic, anhydrous, phenyl salicylate, methylene blue and hyoscyamine sulfate

Antacids containing calcium impair absorption of tetracyclines.

Source: NLP:minocycline hydrochloride

Multivalent cations in antacids form chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 hours after antacids.

Source: NLP:moxifloxacin

Multivalent cations in antacids form chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 hours after antacids.

Source: NLP:moxifloxacin hydrochloride

Multivalent cations in antacids form chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 hours after antacids.

Source: NLP:moxifloxacin hydrochloride tablets, 400 mg

Antacids may interact with iron, potentially affecting iron absorption and efficacy.

Source: NLP:vitamins and minerals

May decrease phenytoin serum levels by affecting absorption; should not be taken at the same time of day.

Source: NLP:extended phenytoin sodium

Calcium-containing antacids may bind phosphate and prevent its absorption.

Source: NLP:potassium phosphate, monobasic and sodium phosphate, monobasic, anhydrous

Decreases raltegravir plasma concentrations. Coadministration not recommended despite no dose adjustment needed for ISENTRESS.

Source: NLP:raltegravir

Antacids decrease rilzabrutinib exposure due to pH-dependent solubility. Administer WAYRILZ at least 2 hours before antacids.

Source: NLP:rilzabrutinib

Antacids interfere with the absorption of risedronate when co-administered.

Source: NLP:risedronate sodium

Reduce diazepam peak concentrations by 30% and slow rate of absorption with 20-25 minute delay in peak achievement, but no effect on extent of absorption.

Source: NLP:diazepam

Antacids can decrease peak concentration of etodolac by 15-20% but have no effect on time-to-peak or extent of absorption.

Source: NLP:etodolac

Bioavailability of olmesartan was not significantly altered by co-administration of aluminum hydroxide/magnesium hydroxide.

Source: NLP:olmesartan medoxomil

Co-administration of Maalox did not affect ziprasidone pharmacokinetics.

Source: NLP:ziprasidone mesylate