Sedatives Interactions

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:buprenorphine and naloxone

CNS depressants cause additive adverse effects with carbinoxamine. Avoid concomitant use.

Source: NLP:carbinoxamine maleate

Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.

Source: NLP:levorphanol tartrate

CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.

Source: NLP:methadone hydrochloride

CNS depressants increase risk of CNS depression. Avoid concomitant use or monitor for adverse reactions.

Source: NLP:metoclopramide

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:nalbuphine hydrochloride

Concomitant use of other sedatives with barbiturates may produce additive central nervous system depressant effects.

Source: NLP:phenobarbital sodium

Promethazine may increase, prolong, or intensify sedative action of these agents.

Source: NLP:promethazine hydrochloride and dextromethorphan hydrobromide

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Either scopolamine or the interacting drug should be chosen depending on importance.

Source: NLP:scopolamine

Possibility of additive or potentiating effect with CNS depressants.

Source: NLP:apraclonidine

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Source: NLP:brimonidine

CNS depressant with potential for additive or potentiating effect when used with brimonidine tartrate ophthalmic solution.

Source: NLP:brimonidine tartrate

CNS depressant with possibility of additive or potentiating effect on central nervous system depression.

Source: NLP:brimonidine tartrate and timolol maleate

Antihistamine component has additive CNS depressant effects with sedatives.

Source: NLP:brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide

Antihistamines have additive effects with sedatives and other CNS depressants.

Source: NLP:brompheniramine maleate, pseudoephedrine hydrochloride,

Sedatives may result in additive or potentiating CNS depressant effects with YUVEZZI.

Source: NLP:carbachol and brimonidine tartrate

Sedatives may have additive CNS depressant effects with cyproheptadine.

Source: NLP:cyproheptadine hydrochloride

Concomitant administration may result in further drowsiness due to CNS depressant effects.

Source: NLP:dantrolene sodium

May potentiate or be potentiated by diazepam action. Careful consideration should be given when combining.

Source: NLP:diazepam

Additive CNS depressant effects with diphenhydramine hydrochloride.

Source: NLP:diphenhydramine hydrochloride

CNS depressants; increased risk of CNS depression. Avoid or monitor for adverse reactions.

Source: NLP:metoclopramide hydrochloride

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Monitor patients or consider choosing one drug over the other.

Source: NLP:scolopamine transdermal system