Gentamicin Interactions

Increases digoxin serum concentration by 129-212%. Requires monitoring and dose reduction of 30-50%.

Source: NLP:digoxin

Gentamicin may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-induced neuromuscular blockade.

Source: NLP:vecuronium bromide

May potentiate renal dysfunction when used concomitantly with cyclosporine. Close monitoring of renal function required.

Source: NLP:cyclosporine

In vitro study showed cytarabine-related antagonism of gentamicin susceptibility against K. pneumoniae. Lack of prompt therapeutic response may indicate need for re-evaluation of antibacterial therapy.

Source: NLP:cytarabine

Aminoglycoside eliminated by active tubular secretion; may increase concentrations of gentamicin and/or emtricitabine/tenofovir.

Source: NLP:efavirenz, emtricitabine and tenofovir disoproxil fumarate

Coadministration may increase concentrations of aminoglycosides and/or tenofovir due to competition for renal tubular secretion. Monitor for tenofovir toxicity.

Source: NLP:emtricitabine and tenofovir disoproxil fumarate

Aminoglycoside that may increase serum tenofovir concentrations and/or increase concentrations of other renally eliminated drugs.

Source: NLP:lamivudine and tenofovir disoproxil fumarate

Piperacillin and tazobactam may inactivate gentamicin in vitro. Separate administration is recommended, though compatibility exists for simultaneous Y-site infusion in certain diluents and concentrations.

Source: NLP:piperacillin and tazobactam

Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence of tenofovir toxicity.

Source: NLP:tenofovir disoproxil fumarate