Potential pharmacodynamic interaction; combined QT prolongation may precipitate arrhythmias.
Source: NLP:droperidol
Antihistamines Interactions
18 interactions on record
Potentiate arrhythmogenic effects of epinephrine; observe carefully for cardiac arrhythmias.
Source: NLP:epinephrine
Produces increased CNS-depressant effects including respiratory depression and sedation.
Source: NLP:lorazepam
Concomitant use may produce additive CNS depressant effects.
Source: NLP:pentobarbital sodium
Concomitant use of antihistamines with barbiturates may produce additive central nervous system depressant effects.
Source: NLP:phenobarbital sodium
Produces additive CNS-depressant effects when co-administered with temazepam.
Source: NLP:temazepam
Amphetamines may counteract the sedative effects of antihistamines.
Source: NLP:amphetamine sulfate
Amphetamines may counteract the sedative effects of antihistamines.
Source: NLP:dextroamphetamine sulfate
Antihistamines + DiazepamModerate
May potentiate or be potentiated by diazepam action. Careful consideration should be given when combining.
Source: NLP:diazepam
May increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride.
Source: NLP:dicyclomine hydrochloride
May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse reactions.
Source: NLP:diphenoxylate hydrochloride and atropine sulfate
Potentiate epinephrine effects and increase arrhythmogenic potential.
Source: NLP:epinephrine in sodium chloride
Antihistamines + EstazolamModerate
May potentiate the action of estazolam; careful consideration of CNS effects needed.
Source: NLP:estazolam
Antihistamines + Heparin SodiumModerate
May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
Source: NLP:heparin sodium
Antihistamines + HistamineModerate
Lessen the skin test wheal and erythema responses elicited by histamine. Should be discontinued at least 5 days before skin testing.
Source: NLP:histamine
Antihistamines + HyaluronidaseModerate
Large doses of antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect; these drugs render tissues partly resistant to hyaluronidase action.
Source: NLP:hyaluronidase
Some antihistamines may cause additive adverse effects from cholinergic blockade when combined with hyoscyamine sulfate.
Source: NLP:hyoscyamine sulfate
Antihistamines + NabiloneModerate
Additive or super-additive tachycardia, drowsiness, and CNS depression reported with concurrent use.
Source: NLP:nabilone