Capecitabine increases exposure of vitamin K antagonists, which may alter coagulation parameters and/or bleeding, potentially resulting in death. Events may occur within days or up to 1 month after discontinuation.
Source: NLP:capecitabine
Vitamin K Antagonists Interactions
3 interactions on record
Nilutamide inhibits cytochrome P-450 isoenzymes, reducing metabolism of vitamin K antagonists and increasing serum half-life, potentially leading to toxic levels. Prothrombin time should be monitored and dosage may need reduction.
Source: NLP:nilutamide
Increased prothrombin time and increased anticoagulant activity reported. Monitoring of anticoagulant activity recommended when pentoxifylline introduced or dose changed.
Source: NLP:pentoxifylline