Sedative-Hypnotics Interactions

Sodium oxybate oral solution is contraindicated for use in combination with sedative hypnotics due to potentiation of CNS-depressant effects.

Source: NLP:sodium oxybate

Sedative-hypnotics may enhance effects causing increased CNS depression.

Source: NLP:butalbital, acetaminophen, and caffeine

Butalbital causes increased CNS depression when combined with sedative-hypnotics.

Source: NLP:butalbital, aspirin, and caffeine

Produces increased CNS-depressant effects including respiratory depression and sedation.

Source: NLP:lorazepam

Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Source: NLP:pentazocine and naloxone

Produces additive CNS-depressant effects when co-administered with temazepam.

Source: NLP:temazepam

Sedative-hypnotics may enhance the effects of butalbital and acetaminophen, causing increased CNS depression.

Source: NLP:butalbital and acetaminophen

Additive CNS depressant effects; reduced dosage of hydromorphone recommended to avoid excessive effects.

Source: NLP:hydromorphone hydrochloride

No dose adjustment needed when co-administered with montelukast sodium.

Source: NLP:montelukast

No dose adjustment needed when co-administered with montelukast sodium.

Source: NLP:montelukast sodium