Trazodone Interactions

Antidepressant metabolized by CYP3A. QT interval prolongation and torsades de pointes reported with coadministration.

Source: NLP:amiodarone hydrochloride

Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjustment.

Source: NLP:hydromorphone hydrochloride

Concomitant use has resulted in serotonin syndrome.

Source: NLP:levorphanol tartrate

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modification; discontinue metaxalone if serotonin syndrome occurs.

Source: NLP:metaxalone

Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation and dose adjustment.

Source: NLP:morphine sulfate

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Source: NLP:nalbuphine hydrochloride

Serotonergic drug that may result in serotonin syndrome when used concomitantly.

Source: NLP:oxymorphone hydrochloride

Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.

Source: NLP:pentazocine and naloxone

Concomitant use may result in serotonin syndrome.

Source: NLP:remifentanil hydrochloride

One report suggested concomitant use may cause 3-6 fold elevations in ALT; however, similar study found no interactive effect on hepatic transaminases.

Source: NLP:buspirone hydrochloride

CYP3A4 inhibitor that increases carbamazepine plasma levels. Close monitoring of carbamazepine levels and dosage adjustment may be required.

Source: NLP:carbamazepine

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:fosphenytoin sodium

Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.

Source: NLP:lasmiditan

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:extended phenytoin sodium

Serotonergic drug may increase risk of serotonin syndrome; requires frequent patient evaluation.

Source: NLP:tapentadol hydrochloride