Levothyroxine Interactions

In vivo studies showed decreased levothyroxine exposure. Postmarketing reports of elevated TSH in patients on thyroid hormone replacement therapy.

Source: NLP:colesevelam hydrochloride

Lanthanum carbonate decreases levothyroxine bioavailability by approximately 40%. Administer at least 2 hours before or after lanthanum carbonate and monitor TSH levels.

Source: NLP:lanthanum carbonate

Hypothyroidism reported with concomitant use. Patients should be monitored for changes in thyroid function. Administer at least 4 hours apart.

Source: NLP:orlistat

Levothyroxine sodium potentiates the effects of epinephrine.

Source: NLP:epinephrine, albuterol sulfate, nitroglycerin, diphenhydramine hydrochloride, aspirin

Cholestyramine may delay or reduce the absorption of thyroxine preparations.

Source: NLP:cholestyramine

Cholestyramine may delay or reduce the absorption of thyroxine preparations.

Source: NLP:cholestyramine powder for suspension

Cholestyramine may delay or reduce absorption of thyroxine.

Source: NLP:choleystyramine light

Levothyroxine sodium may potentiate the effects of epinephrine.

Source: NLP:epinephrine

Patiromer binds levothyroxine, potentially reducing systemic exposure and clinical efficacy. Separate dosing by at least 3 hours.

Source: NLP:patiromer

Salicylate competes with thyroxine for protein binding sites, potentially affecting drug levels.

Source: NLP:salsalate

Semaglutide tablet increased levothyroxine exposure by 33%. Monitor effects and consider increased clinical monitoring with concomitant use.

Source: NLP:semaglutide

Sevelamer carbonate may reduce bioavailability of levothyroxine, which could have clinically significant effect on safety or efficacy. Consider separation of administration timing.

Source: NLP:sevelamer carbonate

Sevelamer may reduce bioavailability of levothyroxine, which has clinically significant effects on safety or efficacy. Consider separation of administration timing.

Source: NLP:sevelamer hydrochloride

Natural or synthetic thyroid hormone that interferes with radioiodide accumulation. Discontinue 4 weeks before procedure.

Source: NLP:sodium iodide i 131

Sodium Polystyrene Sulfonate may bind thyroxine and decrease its gastrointestinal absorption. Administer at least 3 hours before or after Sodium Polystyrene Sulfonate.

Source: NLP:sodium polystyrene sulfonate

Bioavailability of alendronate was slightly decreased when co-administered with levothyroxine.

Source: NLP:alendronate sodium

In vivo testing showed no clinically significant changes in levothyroxine exposure when co-administered with LOKELMA.

Source: NLP:sodium zirconium cyclosilicate