Tacrine Interactions

Coadministration increased tacrine Cmax and AUC five- and eight-fold, causing nausea, vomiting, sweating, and diarrhea.

Source: NLP:fluvoxamine maleate

Deferasirox inhibits CYP1A2 resulting in increased tacrine concentration. Monitor for exposure related toxicity.

Source: NLP:deferasirox

Fexinidazole inhibits CYP1A2, increasing tacrine concentrations and risk of adverse reactions.

Source: NLP:fexinidazole

Inhibits theophylline metabolism, resulting in increased serum theophylline concentrations. May require dose reduction to avoid toxicity.

Source: NLP:theophylline