Venlafaxine Hydrochloride + Ketoconazole Interaction
Unknowninteraction on record
Description
Ketoconazole A pharmacokinetic study with ketoconazole 100 mg b.i.d. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6, respectively, resulted in higher plasma concentrations of both venlafaxine and O-desvenlafaxine (ODV) in most subjects following administration of ketoconazole.
Source: FDA drug label - venlafaxine hydrochloride