Lumacaftor And Ivacaftor + Itraconazole Interaction
Unknowninteraction on record
Description
( 2.3 , 7 , 12.3 ) Potential for Other Drugs to Affect Lumacaftor/Ivacaftor 7.1 Inhibitors of CYP3A Co-administration of lumacaftor/ivacaftor with itraconazole, a strong CYP3A inhibitor, did not impact the exposure of lumacaftor, but increased ivacaftor exposure by 4.3-fold. Examples of strong CYP3A inhibitors include: ketoconazole, itraconazole, posaconazole, and voriconazole. 7.8 Antifungals Concomitant use of ORKAMBI may reduce the exposure and effectiveness of itraconazole, ketoconazole, posaconazole, and voriconazole.
Source: FDA drug label - lumacaftor and ivacaftor