Leflunomide And Diclofenac Sodium Gel + Leflunomide Interaction
Unknowninteraction on record
Description
7 DRUG INTERACTIONS Following oral administration, leflunomide is metabolized to an active metabolite, teriflunomide, which is responsible for essentially all of leflunomide's in vivo activity. Drug interaction studies have been conducted with both leflunomide and with its active metabolite, teriflunomide, where the metabolite was directly administered to the test subjects. Effect of potent CYP and transporter inducers Leflunomide is metabolized by CYP450 metabolizing enzymes.
Source: FDA drug label - leflunomide and diclofenac sodium gel