Fluconazole + Methadone Interaction
Unknowninteraction on record
Description
ketoconazole), protease inhibitors (e.g., ritonavir), fluconazole, fluvoxamine, some selective serotonin reuptake inhibitors (SSRIs) (e.g., sertraline, fluvoxamine) Inducers of CYP3A4, CYP2B6, CYP2C19, or CYP2C9 Clinical Impact: The concomitant use of methadone hydrochloride tablets and CYP3A4, CYP2B6, CYP2C19, or CYP2C9 inducers can decrease the plasma concentration of methadone [see CLINICAL PHARMACOLOGY ( 12.3 ) ], resulting in decreased efficacy or onset of withdrawal symptoms in patients physically dependent on methadone.
Source: FDA drug label - methadone