Conjugated Estrogens And Medroxyprogesterone Acetate + Aminoglutethimide Interaction
Unknowninteraction on record
Description
• Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism ( 7.1 ) • Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of medroxyprogesterone acetate ( 7.1 ) 7.1 Metabolic Interactions In vitro and in vivo studies have shown that estrogens are metabolized partially by cytochrome P450 3A4 (CYP3A4). Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of MPA.
Source: FDA drug label - conjugated estrogens and medroxyprogesterone acetate