Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Atazanavir Interaction
Moderateinteraction on record
Description
Other PIs with CYP3A4 inhibitory activity (atazanavir and atazanavir/ritonavir) resulted in elevated levels of buprenorphine and norbuprenorphine, and patients in one study reported increased sedation. Symptoms of opioid excess have been found in post-marketing reports of patients receiving buprenorphine and atazanavir with and without ritonavir concomitantly. Intervention: Monitor patients taking Buprenorphine and Naloxone Sublingual Tablets and atazanavir with and without ritonavir, and reduce dose of Buprenorphine and Naloxone Sublingual Tablets if warranted.
Source: FDA drug label - buprenorphine hydrochloride and naloxone hydrochloride dihydrate