Azelastine Hydrochloride%2C Fluticasone Propionate + Ritonavir Interaction
Unknowninteraction on record
Description
Ritonavir: Coadministration is not recommended. 7.2 Cytochrome P450 3A4 Ritonavir (a strong CYP3A4 inhibitor) significantly increased plasma fluticasone propionate exposure following administration of fluticasone propionate aqueous nasal spray, resulting in significantly reduced serum cortisol concentrations [see Clinical Pharmacology (12.3)] . During postmarketing use, there have been reports of clinically significant drug interactions in patients receiving fluticasone propionate and ritonavir, resulting in systemic corticosteroid effects including Cushing syndrome and adrenal suppression.
Source: FDA drug label - azelastine hydrochloride, fluticasone propionate