Alprazolam C Iv + Ritonavir Interaction
Contraindicatedinteraction on record
Description
Strong Inhibitors of CYP3A (except ritonavir) Clinical implication Concomitant use of alprazolam with strong CYP3A inhibitors has a profound effect on the clearance of alprazolam, resulting in increased concentrations of alprazolam and increased risk of adverse reactions [see CLINICAL PHARMACOLOGY (12.3)]. Prevention or management Concomitant use of alprazolam with a strong CYP3A4 inhibitor (except ritonavir) is contraindicated [see CONTRAINDICATIONS (4), WARNINGS AND PRECAUTIONS (5.5)]. Examples Carbamazepine, phenytoin Ritonavir Clinical implication Interactions involving ritonavir and alprazolam are complex and time dependent.
Source: FDA drug label - alprazolam c-iv