Acetaminophen And Codeine Phosphate + Ritonavir Interaction
Majorinteraction on record
Description
ketoconazole), and protease inhibitors(e.g., ritonavir), may result in an increase in codeine plasma concentrations , with subsequently greater metabolism by CYP2D6, resulting in greater morphine levels, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression, particularly when an inhibitor is added after a stable dose of acetaminophen and codeine phosphate tablets is achieved (see WARNINGS ).
Source: FDA drug label - acetaminophen and codeine phosphate