Pazopanib + EsomeprazoleUnknown
7.4 Concomitant Use With Gastric Acid-Reducing Agents Concomitant use of pazopanib tablets with esomeprazole, a PPI, decreased the exposure of pazopanib.
Source: FDA drug label - pazopanib
Pazopanib Interactions
Brand names: Pazopanib
2 interactions on record
Pazopanib + SimvastatinUnknown
( 7.2 ) Concomitant Use With Simvastatin: Concomitant use of pazopanib tablets with simvastatin increases the risk of alanine aminotransferase (ALT) elevations. 7.3 Concomitant Use With Simvastatin Concomitant use of pazopanib tablets with simvastatin increases the incidence of ALT elevations. Across clinical trials of pazopanib tablets as a single agent, ALT > 3 x ULN was reported in 126/895 (14%) of patients who did not use statins compared with 11/41 (27%) of patients who had concomitant use of simvastatin.
Source: FDA drug label - pazopanib