Conversely, the pharmacokinetics of quinidine are not significantly affected by caffeine, ciprofloxacin, digoxin, felodipine, omeprazole, or quinine .
Source: FDA drug label - quinidine gluconate
Quinidine Gluconate Interactions
Brand names: Quinidine Gluconate
12 interactions on record
Interactions with other dihydropyridine calcium channel blockers have not been reported, but these agents (including felodipine, nicardipine, and nimodipine ) are all dependent upon P450 IIIA4 for metabolism, so similar interactions with quinidine should be anticipated. Conversely, the pharmacokinetics of quinidine are not significantly affected by caffeine, ciprofloxacin, digoxin, felodipine, omeprazole, or quinine .
Source: FDA drug label - quinidine gluconate
In the case of prodrugs whose actions are actually mediated by P450 IID6 -produced metabolites (for example, codeine and hydrocodone , whose analgesic and antitussive effects appear to be mediated by morphine and hydromorphone, respectively), it may not be possible to achieve the desired clinical benefits in poor metabolizers.
Source: FDA drug label - quinidine gluconate
Perhaps because of competition for the P450 IIIA4 metabolic pathway, quinidine levels rise when ketoconazole is coadministered.
Source: FDA drug label - quinidine gluconate
Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of diltiazem, flecainide, mephenytoin, metoprolol, propafenone, propranolol, quinine, timolol, or tocainide .
Source: FDA drug label - quinidine gluconate
Interactions with other dihydropyridine calcium channel blockers have not been reported, but these agents (including felodipine, nicardipine, and nimodipine ) are all dependent upon P450 IIIA4 for metabolism, so similar interactions with quinidine should be anticipated.
Source: FDA drug label - quinidine gluconate
Very rarely, and again by mechanisms not understood, quinidine levels are decreased by coadministration of nifedipine . Presumably because both drugs are metabolized by cytochrome P450 IIIA4 , coadministration of quinidine causes variable slowing of the metabolism of nifedipine .
Source: FDA drug label - quinidine gluconate
Interactions with other dihydropyridine calcium channel blockers have not been reported, but these agents (including felodipine, nicardipine, and nimodipine ) are all dependent upon P450 IIIA4 for metabolism, so similar interactions with quinidine should be anticipated.
Source: FDA drug label - quinidine gluconate
Conversely, the pharmacokinetics of quinidine are not significantly affected by caffeine, ciprofloxacin, digoxin, felodipine, omeprazole, or quinine .
Source: FDA drug label - quinidine gluconate
Perhaps by competing for pathways of renal clearance, coadministration of quinidine causes an increase in serum levels of procainamide .
Source: FDA drug label - quinidine gluconate
Coadministration of propranolol usually does not affect quinidine pharmacokinetics, but in some studies the β-blocker appeared to cause increases in the peak serum levels of quinidine, decreases in quinidine's volume of distribution, and decreases in total quinidine clearance. Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of diltiazem, flecainide, mephenytoin, metoprolol, propafenone, propranolol, quinine, timolol, or tocainide .
Source: FDA drug label - quinidine gluconate
Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of diltiazem, flecainide, mephenytoin, metoprolol, propafenone, propranolol, quinine, timolol, or tocainide .
Source: FDA drug label - quinidine gluconate