Asciminib Interactions

( 7.1 ) Itraconazole Oral Solution Containing Hydroxypropyl-β-cyclodextrin: Avoid concomitant use of SCEMBLIX at all recommended doses. Itraconazole Oral Solution Containing Hydroxypropyl-β-cyclodextrin Concomitant use of SCEMBLIX with itraconazole oral solution containing hydroxypropyl-β-cyclodextrin decreases asciminib C max and AUC, which may reduce SCEMBLIX efficacy [see Clinical Pharmacology (12.3)] . Avoid coadministration of SCEMBLIX at all recommended doses with itraconazole oral solution containing hydroxypropyl-β-cyclodextrin.

Source: FDA drug label - asciminib

( 7.2 ) Substrates of BCRP: Avoid concomitant use with rosuvastatin at all recommended doses. Avoid coadministration of SCEMBLIX at all recommended doses with rosuvastatin.

Source: FDA drug label - asciminib