Darolutamide Interactions

( 2.4 , 5.1 , 7.3 , 12.3 ) Cyclosporine and darolutamide: Combination increases rosuvastatin exposure. 7.4 Darolutamide Darolutamide increased rosuvastatin exposure more than 5 fold. Therefore, in patients taking darolutamide, the dose of rosuvastatin tablets should not exceed 5 mg once daily [ see Dosage and Administration (2.4), Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

Source: FDA drug label - rosuvastatin

Darolutamide Clinical Impact: Darolutamide increased rosuvastatin exposure more than 5-fold. Intervention: In patients taking darolutamide, do not exceed a dose of rosuvastatin 5 mg once daily.

Source: FDA drug label - rosuvastatin calcium