Brand names: Probenecid And Colchicine
4 interactions on record
Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. Since probenecid decreases the renal excretion of conjugated sulfonamides, plasma concentrations of the latter should be determined from time to time when a sulfonamide and probenecid and colchicine are coadministered for prolonged periods.
Source: FDA drug label - probenecid and colchicine
These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin.
Source: FDA drug label - probenecid and colchicine
Drug Interactions When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. In the case of penicillin, or other beta-lactams, psychic disturbances have been reported.
Source: FDA drug label - probenecid and colchicine
The uricosuric action of probenecid is also antagonized by pyrazinamide.
Source: FDA drug label - probenecid and colchicine