The absorption of verapamil can be reduced by the cyclophosphamide, oncovin, procarbazine, prednisone (COPP) and the vindesine, adriamycin, cisplatin (VAC) cytotoxic drug regimens.
Source: FDA drug label - verapamil hydrochloride
Verapamil Hydrochloride Interactions
Brand names: Verapamil Hydrochloride
15 interactions on record
A variable effect has been seen when verapamil and atenolol were given together.
Source: FDA drug label - verapamil hydrochloride
Lower starting and maintenance doses of other CYP3A4 substrates (e.g., atorvastatin) may be required as verapamil may increase the plasma concentration of these drugs.
Source: FDA drug label - verapamil hydrochloride
The absorption of verapamil can be reduced by the cyclophosphamide, oncovin, procarbazine, prednisone (COPP) and the vindesine, adriamycin, cisplatin (VAC) cytotoxic drug regimens.
Source: FDA drug label - verapamil hydrochloride
Antiarrhythmic agents: Disopyramide: Until data on possible interactions between verapamil and disopyramide are obtained, disopyramide should not be administered within 48 hours before or 24 hours after verapamil administration.
Source: FDA drug label - verapamil hydrochloride
Clinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.
Source: FDA drug label - verapamil hydrochloride
Limit the daily dose of lovastatin to 40 mg.
Source: FDA drug label - verapamil hydrochloride
A decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.
Source: FDA drug label - verapamil hydrochloride
Such an effect was observed in one study following the concomitant administration of verapamil and prazosin.
Source: FDA drug label - verapamil hydrochloride
A decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.
Source: FDA drug label - verapamil hydrochloride
Mammalian target of rapamycin (mTOR) inhibitors: In a study of 25 healthy volunteers with co-administration of verapamil with sirolimus, whole blood sirolimus C max and AUC were increased 130% and 120%, respectively.
Source: FDA drug label - verapamil hydrochloride
Clinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.
Source: FDA drug label - verapamil hydrochloride
Coadministration of multiple doses of 10 mg of verapamil with 80 mg simvastatin resulted in exposure to simvastatin 2.5-fold that following simvastatin alone. Limit the dose of simvastatin in patients on verapamil to 10 mg daily.
Source: FDA drug label - verapamil hydrochloride
Telithromycin: Hypotension and bradyarrhythmias have been observed in patients receiving concurrent telithromycin, an antibiotic in the ketolide class.
Source: FDA drug label - verapamil hydrochloride
Asymptomatic bradycardia (36 beats/min) with a wandering atrial pacemaker has been observed in a patient receiving concomitant timolol (a beta-adrenergic blocker) eyedrops and oral verapamil.
Source: FDA drug label - verapamil hydrochloride