Ospemifene Interactions

Brand names: Osphena

2 interactions on record

Ospemifene + FluconazoleContraindicated

( 7.1 , 12.3 ) Do not use fluconazole concomitantly with OSPHENA. Fluconazole increases serum concentrations of OSPHENA. 7.2 Fluconazole Do not use OSPHENA concomitantly with fluconazole, a moderate CYP3A / strong CYP2C9 / moderate CYP2C19 inhibitor.

Source: FDA drug label - ospemifene

Ospemifene + KetoconazoleUnknown

7.4 Ketoconazole Ketoconazole, a strong CYP3A4 inhibitor, increases the systemic exposure of ospemifene by 1.4-fold. Administration of ketoconazole chronically with ospemifene may increase the risk of OSPHENA-related adverse reactions [see Clinical Pharmacology (12.3) ] .

Source: FDA drug label - ospemifene